Novel Tumor Suppressors: The Human G2 Checkpoint Genes

Normal

Normal eukaryotic cells cease to divide when they experience damage to the DNA caused by chemotherapy or radiation.  This phenomenon is termed the “DNA damage-induced checkpoint response”.   These checkpoints in the cell division cycle play a critical role in the maintenance of genomic integrity.  Cells that are mutated in one of the cell cycle checkpoint genes are unable to stop cell cycle progression even in the presence of DNA damage.  This can lead to increased rates of tumor formation and therefore checkpoint genes are termed tumor suppressors. 

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Comments

[steven]

Thank you for information.